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Khan, Zaid, 2016. Obesity-linked genes' regulation in Drosophila melanogaster. Second cycle, A1E. Uppsala: SLU, Dept. of Microbiology



There are several serious diseases such as cancer, diabetes and obesity in this modern world. Insects are mostly used to investigate the functions of neuropeptides in regulation of feeding behavior and starvation. In D. melanogaster the regulation of Twz, TfAp2, Hmgcr and G9a were significantly affected by different periods of starvation. The expression of Twz and TfAP-2 in adult flies controls the secretion and production of octopamine that regulates the function of Drosulfakinin (DSK) and Drosophila cholecystokinin (CCK). In D. melanogaster Hmgcr is produced in the pars intercerbralis (PI) region of the brain and was supposed to regulate feeding behavior but the regulation of feeding was not affected either by Hmgcr nor G9a on different nutrient condition. Hmgcr catalyzes the production of mevalonate; the precursors of juvenile hormone (JH) component.

Main title:Obesity-linked genes' regulation in Drosophila melanogaster
Authors:Khan, Zaid
Supervisor:Blomqvist, Johanna
Examiner:Passoth, Volkmar
Series:Examensarbete / Sveriges lantbruksuniversitet, Institutionen för mikrobiologi
Volume/Sequential designation:2016:10
Year of Publication:2016
Level and depth descriptor:Second cycle, A1E
Student's programme affiliation:None
Supervising department:(NL, NJ) > Dept. of Microbiology
Keywords:obesity linked-genes, starvation in Drosophila, TfAP-2, Twz
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Subject. Use of subject categories until 2023-04-30.:Life sciences
Deposited On:25 Nov 2016 10:50
Metadata Last Modified:25 Nov 2016 10:50

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