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Mohammad, Imran, 2015. Role of estrogen nuclear receptor (ER) in T helper cells. Second cycle, A2E. Uppsala: SLU, Dept. of Microbiology

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Abstract

Multiple studies have demonstrated that estrogen (17β Estradiol) affects innate and adaptive immune systems. Its role as protective factor has been implicated in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Estrogen exerts its action on immune cells using estrogen nuclear receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). T helper (Th) cells are key regulators of the adaptive immune system. However, the mechanism how estrogen regulates T helper subset cells is still uncertain. To study the effect of estrogen and molecular mechanism, I silenced the estrogen alpha receptor gene that is predominantly expressed in T cells, by using siRNA approach. I observed that knock down of ERα is affecting Th1 by elevating T-bet, Th2 by increasing GATA3 and Treg by reducing Foxp3 levels. The outcome of this thesis will help in understanding pathophysiological effects of T helper cells and also the role of estrogen receptors in T cells and their effects in cancer immunity and autoimmunity.

Main title:Role of estrogen nuclear receptor (ER) in T helper cells
Authors:Mohammad, Imran
Supervisor:Passoth, Volkmar and Chen, Zhi Jane
Examiner:Pejler, Gunnar
Series:Examensarbete / Sveriges lantbruksuniversitet, Institutionen för mikrobiologi
Volume/Sequential designation:2015:2
Year of Publication:2015
Level and depth descriptor:Second cycle, A2E
Student's programme affiliation:NM003 Biotechnology - Master's Programme 120 HEC
Department:(NL, NJ) > Dept. of Microbiology
Keywords:Estrogen receptor alpha, T helper cells, T helper subsets, autoimmunity, Estrogen (17β Estradiol)
URN:NBN:urn:nbn:se:slu:epsilon-s-4695
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-s-4695
Subjects:Life sciences
Human medicine, health, and safety
Language:English
Deposited On:14 Jul 2015 12:13
Metadata Last Modified:14 Jul 2015 12:13

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