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Mared, Malin, 2010. Glucose markers in healthy and diabetic bitches in different stages of the oestral cycle. Second cycle, A1N, A1F or AXX ( AXX). Uppsala: SLU, Dept. of Clinical Sciences

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Abstract

The female dog has a unique reproductive endocrinology, with high levels of progesterone throughout the 70-day long luteal phase. In this project, markers of glucose metabolism were studied and compared from the aspects of breed group and time in oestral cycle. The parameters studied were: glucose, insulin, progesterone, fructosamine and the newly introduced analysis of HbA1c. Hba1c was also further evaluated and discussed as a diagnostic tool in canine medicine.

No differences in terms of glucose markers were found between a group of purebreed dogs of various breeds compared to a group of dogs with high risk of dioestrus diabetes, namely the Norwegian and Swedish elkhounds.

No differences were found between the two sample occasions, anoestrus and dioestrus, concluding that there is no need for relating test results to the time of the oestrous cycle in middle-aged intact female dogs.

There were statistically significant higher values of all glucose markers in diabetic dogs than in non-diabetic dogs. When it came to HbA1c, however, there was a larger overlap between the two groups, compared to fructosamine. The HbA1c
analysis was easy to perform, but was found to have a low precision. It was not possible to compare the results of HbA1c with other studies, since there is no agreement of a standardized method. The author therefore concludes that if
HbA1c is to be used in veterinary medicine, reference values for the specific laboratory and analytic method needs to be set up.

Main title:Glucose markers in healthy and diabetic bitches in different stages of the oestral cycle
Authors:Mared, Malin
Supervisor:Fall, Tove
Examiner:Jones, Bernt
Series:Examensarbete inom veterinärprogrammet, Uppsala 2010 Fakulteten för Veterinärmedicin och husdjursvetenskap Institutionen för kliniska vetenskaper
Volume/Sequential designation:2010:1
Year of Publication:2010
Level and depth descriptor:Second cycle, A1N, A1F or AXX
Student's programme affiliation:3050A Veterinary Medicine Programme (admitted before July 1, 2007) 330 HEC
Department:(VH) > Dept. of Clinical Sciences
Keywords:Diabetes, HbA1c, insulin, progesteron, glukos
URN:NBN:urn:nbn:se:slu:epsilon-6-120
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-6-120
Subjects:Animal diseases
Animal physiology and biochemistry
Language:English
Deposited On:29 Jan 2010 11:28
Metadata Last Modified:20 Apr 2012 14:11

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