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Ali, Nadeem, 2007. Teratology in zebrafish embryos : a tool for risk assessment. Second cycle, A1N, A1F or AXX ( AXX). Uppsala: SLU, Dept. of Biomedical Sciences and Veterinary Public Health

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Abstract

Teratology, study of abnormal prenatal development, as a descriptive science has starts with written language. The modern experimental teratology era started in the early quarter of 20th centaury. Since the thalidomide catastrophe in early 1960s regulatory agencies launched requirements for new drugs to be thoroughly tested on animals prior
to human use. One of the major concerns in the teratological studies is the mechanism of teratogenesis; it is very difficult to know the exact mechanism of teratogenesis. However there are many proposed
mechanism of teratogenesis by Wilson 1973. Teratogens induce one or multiple unique pathogenic responses in the developing embryos. Susceptibility f teratogenesis varies with age and therefore can be divided into three developmental periods: early embryonic
development, organogenesis and early differentiation, and late embryonic development. Animal based studies provide the initial guideline if a chemical or drug may present a teratogenic risk. A variety of laboratory animals
from different classes of animals are being used for the teratological studies. Rat, rabbit, mice, hamster, and non human primates are the most prevalent laboratory animal species of the mammal class. Xenopus laevis of the amphibian class has been used and suggested as
a model for mammalian teratogenicity. From the bird class chicken, duck and quail have been used most often in laboratory studies. Zebrafish, Japanese medaka and fathead minnow are the most commonly used laboratory fish species, promoted by OECD for future testing of chemical toxicity. Teratogens can be classified as recreational and social teratogens, pharmaceutical teratogens, industrial and environmental teratogens, agricultural teratogens, and
metabolic and infectious diseases. In the present study model substances were selected from the different classes of teratogens. The selected substances were; retinoic acid, lithium, ethanol, 6-aminonicotinamide, ochratoxin A and arsenic,

Main title:Teratology in zebrafish embryos
Subtitle:a tool for risk assessment
Authors:Ali, Nadeem
Supervisor:UNSPECIFIED
Examiner:UNSPECIFIED
Series:Report / International Master of Science Programme, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences
Volume/Sequential designation:65
Year of Publication:2007
Level and depth descriptor:Second cycle, A1N, A1F or AXX
Student's programme affiliation:MSCVE Master of Science Programme in Veterinary Medicine 90 HEC
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Keywords:teratology, teratogenesis, retinoic acid, lithium, ethanol, 6-aminonicotinamide, ochratoxin A, arsenic, zebrafish
URN:NBN:urn:nbn:se:slu:epsilon-s-670
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-s-670
Subjects:Animal diseases
Language:English
Additional Information:Överförd från avhandlingsarkivet / Transferred from the Dissertations and Graduate Theses Archive
Deposited On:11 Nov 2011 13:44
Metadata Last Modified:20 Apr 2012 14:22

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