Metreveli, Giorgi, 2006. Expression of influenza virus nonstructural protein 1 (NS1). Second cycle, A1N, A1F or AXX ( AXX). Uppsala: SLU, Dept. of Biomedical Sciences and Veterinary Public Health (until 231231)
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Abstract
Avian influenza poses a threat to many species including man, as shown by the current scenario in Southeast Asia. It appears that this particular type of influenza
virus can spread to many species causing severe disease in these new species. For example, from 258 human cases 154 were fatal (WHO, 2006-11-29). Why some avian influenza virus have the ability to infect other species remains to be
understood. One viral gene, coding for the non-structural protein 1 (NS1), appears to be an important factor for successfully transmission into a new host, by counteracting
the new host’s immune system. The exact mechanism of action of NS1 is still unclear, but leads to down-regulation of various pathways of the immune defence. The aim of this study was to express NS1 proteins of influenza viruses
originating from different hosts, including highly pathogenic avian influenza viruses, for use in investigations on the mechanism used by NS1 to interfere with the immune system of various hosts. In particular, studies on the interaction of NS1 with the RNA dependent protein kinase (PKR) were initiated, to determine
differences in this interaction between high and low pathogenic influenza viruses from different hosts. By establishing tools and optimised assays, the work enables
further studies on the role NS1 in immune evasion.
| Main title: | Expression of influenza virus nonstructural protein 1 (NS1) |
|---|---|
| Authors: | Metreveli, Giorgi |
| Supervisor: | UNSPECIFIED |
| Examiner: | UNSPECIFIED |
| Series: | Report / International Master of Science Programme, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences |
| Volume/Sequential designation: | 59 |
| Year of Publication: | 2006 |
| Level and depth descriptor: | Second cycle, A1N, A1F or AXX |
| Student's programme affiliation: | MSCVE Master of Science Programme in Veterinary Medicine 90 HEC |
| Supervising department: | (VH) > Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) |
| Keywords: | influenza virus, NS1, PKR, avian flu |
| URN:NBN: | urn:nbn:se:slu:epsilon-s-657 |
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-s-657 |
| Subject. Use of subject categories until 2023-04-30.: | Animal diseases Human medicine, health, and safety |
| Language: | English |
| Additional Information: | Överförd från avhandlingsarkivet / Transferred from the Dissertations and Graduate Theses Archive |
| Deposited On: | 27 Oct 2011 13:43 |
| Metadata Last Modified: | 20 Apr 2012 14:22 |
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