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Svanström, Peter, 2011. Proliferativ enteropati hos gris : patogenes och patologiska förändringar. First cycle, G2E. Uppsala: SLU, Dept. of Biomedical Sciences and Veterinary Public Health

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Abstract

Proliferative enteropathy is a group of disease conditions in pigs where the disease may vary from subclinical to critical with bloody loose feces. The etiological agent is the obligate intracellular bacteria Lawsonia intracellularis.
L. intracellularis infects enterocytes from jejunum to colon. The bacteria is taken into cells and start to replicate and cause a massive proliferation of immature enterocytes. There are several aspects in the pathogenesis of proliferative enteropathy that today remain unclear. As an example, it is not yet established how the bacteria invade cells. How the massive proliferation of enterocytes is induced after bacterial uptake into cells also remains unclear. It has been suggested that the uptake of bacteria could be a type of receptor mediated endocytosis and that the massive proliferation is the result of a bacterial regulation of cell differentiation- and/or apoptosis genes.
The different conditions are porcine intestinal adenomatosis/chronic proliferative enteropathy, proliferative hemorrhagic-/acute hemorrhagic enteropathy, necrotic enteritis and regional ileitis. In all conditions there is a thickening of the mucosa in the affected portion of the intestine due to a massive proliferation of immature enterocytes. In addition to this basic lesion additional changes are seen in proliferative hemorrhagic-/acute hemorrhagic enteropathy, necrotic enteritis and regional ileitis.
How L. intracellularis give rise to disease and how it induce the macroscopic lesions is still unknown and further research is therefore important.

Main title:Proliferativ enteropati hos gris
Subtitle:patogenes och patologiska förändringar
Authors:Svanström, Peter
Supervisor:Olofsson, Karin
Examiner:Fredriksson, Mona
Series:Veterinärprogrammet, examensarbete för kandidatexamen / Sveriges lantbruksuniversitet, Institutionen för biomedicin och veterinär folkhälsovetenskap (t.o.m. 2015)
Volume/Sequential designation:2011:06
Year of Publication:2011
Level and depth descriptor:First cycle, G2E
Student's programme affiliation:VY002 Veterinary Medicine Programme 330 HEC
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Keywords:Proliferativ, Enteropati, Lawsonia, Hemorragisk, Regional, Nekrotisk, Patogenes
URN:NBN:urn:nbn:se:slu:epsilon-s-18
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-s-18
Language:Swedish
Deposited On:07 Apr 2011 10:25
Metadata Last Modified:20 Apr 2012 14:18

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