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Bengtsdotter, Elin, 2011. Upprepad intravenös administrering av trimetoprim-sulfadiazin hos neonatala föl. Second cycle, A1N, A1F or AXX ( AXX). Uppsala: SLU, Dept. of Clinical Sciences

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Abstract

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses. However, in this study the plasma concentrations do not exceed MIC (minimum inhibitory concentration) for the most common sepsis pathogens during the entire dose interval. Therefore, it may be recommended to administer trimethoprim-sulfadiazine at a dosage of 15 mg/kg bodyweight three times daily in foals.

Main title:Upprepad intravenös administrering av trimetoprim-sulfadiazin hos neonatala föl
Authors:Bengtsdotter, Elin
Supervisor:Bröjer, Johan and Ingvast Larsson, Carina
Examiner:Jones, Bernt
Series:Examensarbete (Sveriges lantbruksuniversitet, Fakulteten för veterinärmedicin och husdjursvetenskap, Veterinärprogrammet)
Volume/Sequential designation:2011:30
Year of Publication:2011
Level and depth descriptor:Second cycle, A1N, A1F or AXX
Student's programme affiliation:3050A Veterinary Medicine Programme (admitted before July 1, 2007) 330 HEC
Department:(VH) > Dept. of Clinical Sciences
Keywords:sepsis, föl, trimetoprim, sulfadiazin
URN:NBN:urn:nbn:se:slu:epsilon-6-463
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-6-463
Subjects:Veterinary science and hygiene - General aspects
Language:Swedish
Deposited On:22 Mar 2011 08:40
Metadata Last Modified:20 Apr 2012 14:18

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