Home About Browse Search

Berglund, Madeleine, 2023. SETARIA DIGITATA : novel findings of antigen protein/nucleotide and sequential anti-filarial protein/drug targets for drug development in Setaria Digitata. Second cycle, A2E. Uppsala: SLU, Dept. of Animal Breeding and Genetics (until 231231)

Full text not available


Bioinformatics is a way to utilize data in a technique to investigate genes on genomic levels. The nematode Setaria Digitata genome has been sequenced in a study and the genome was found to consist of a large number of genes, as expected which in turn requires more annotation. Therefore, there is a need to find relevant genes within this nematode for potential drug development. Filarial disease is a catastrophic endemic disease that occurs mainly in poor socio-economic areas. Setaria Digitata is the cattle lymphatic filariasis nematode, while the human lymphatic filariasis can be caused by Wuchereria Bancrofti, Brugia Malayi and Brugia Timori with Wuchereria being the main causative agent. Mass drug administration, constructed by health organizations has been an effective way to combat this disease, however, medicine resistance has proven to be a barrier in these processes. Therefore, there exists demand to develop new drugs or vaccines. In this study Setaria Digitata genome sequences are compared to several relevant genes that are proven to be protein/drug targets, have been known to inhibit, alter or are the antigen of filariasis nematodes. These results are analysed and compared towards each other. Different methods including pairwise alignment, remote blast and protein structure similarity was utilized based on a comprehensive literature survey. The results proved that S. Digitata genome contains several relevant genes that are significantly alike human pathogenic nematodes such as Transglutaminase with a similarity of close to 90% and nematodes, as for example Brugia Malayi with a 78.75% identical similarity, therefore it demonstrates the possibility of the nematode Setaria Digitata to be used as a model genome to the filariasis nematodes helping drug development of the disease.

Subtitle:novel findings of antigen protein/nucleotide and sequential anti-filarial protein/drug targets for drug development in Setaria Digitata
Authors:Berglund, Madeleine
Supervisor:Bongcam Rudloff, Erik and Coulbourn Flores, Samuel
Examiner:Andersson, Göran
Volume/Sequential designation:UNSPECIFIED
Year of Publication:2023
Level and depth descriptor:Second cycle, A2E
Student's programme affiliation:None
Supervising department:(VH) > Dept. of Animal Breeding and Genetics (until 231231)
Keywords:Setaria Digitata, nematode, filariasis disease, drug design
Permanent URL:
Deposited On:08 Sep 2023 06:18
Metadata Last Modified:09 Sep 2023 01:03

Repository Staff Only: item control page


Downloads per year (since September 2012)

View more statistics