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Josefsson, Ida, 2020. Presence of hypergonadotropic hypogonadism in dogs with primary adrenocortical insufficiency. Second cycle, A2E. Uppsala: SLU, Dept. of Clinical Sciences (until 231231)



Primary adrenocortical insufficiency (PAI) is a complex endocrine dysfunction that can occur
in both dogs and humans. The three layers of the adrenal cortex are destroyed, which is most
often an autoimmune process. There is evidence of other autoimmune endocrinopathies, such
as hypothyroidism, occurring concurrently with PAI in dogs. This is also known in humans
with PAI, as part of autoimmune polyendocrine syndromes that are genetically linked.
Sometimes these syndromes can include dysfunction of the gonads, and a consequential hypergonadotropic hypogonadism (HH).
The aim of this study was to investigate whether there is a connection between PAI and HH in
dogs. Twenty intact Swedish dogs with PAI were selected from the patient records of the
University of Agricultural Sciences animal hospital to be included in the study. Serum specimen
were acquired and analysed for luteinizing hormone using a semi-quantitative rapid immunechromatographic essay. A positive test was interpreted as confirmed HH and a negative result
as non-HH. A third category, suspected HH, was used for the cases when a clear test band was
discernible of lower intensity than the control band. Animal hospital journals were utilized to
acquire additional information about the dogs, such as for example whether they were
diagnosed with other endocrinopathies.
The female to male proportion of the dogs was 60% to 40% and the most common breed was
Standard Poodle. The age of the dogs ranged from 2 to 10 years, with a median of 7 years.
Phenotypically, the study group was comparable to what previously has been reported in studies
on PAI. Out of the 20 dogs in this study, none had a clear positive result on the rapid essay.
However, three dogs (15%), one female and two male dogs, were classified as having suspected
HH. Interestingly two of these three dogs had concurrent hypothyroidism.
The present study shows that HH may be present in dogs with PAI, and that suspected HH may
occur in dogs with concurrent polyendocrine diseases. More studies are needed, including
larger sample size and quantitative hormone analysis, before presence of HH can be confirmed
in dogs with PAI.

Main title:Presence of hypergonadotropic hypogonadism in dogs with primary adrenocortical insufficiency
Authors:Josefsson, Ida
Supervisor:Hansson, Jeanette
Examiner:Hagman, Ragnvi
Volume/Sequential designation:UNSPECIFIED
Year of Publication:2020
Level and depth descriptor:Second cycle, A2E
Student's programme affiliation:VY002 Veterinary Medicine Programme 330 HEC
Supervising department:(VH) > Dept. of Clinical Sciences (until 231231)
Keywords:primary adrenocortical insufficiency, addison´s disease, dog, hypergonadotropic hypogonadism, autoimmune polyendocrine syndromes, luteinizing hormone
Permanent URL:
Subject. Use of subject categories until 2023-04-30.:Animal diseases
Deposited On:03 Feb 2021 09:34
Metadata Last Modified:11 Jun 2022 23:15

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