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Selling, Kristin, 2020. Resistant E. coli isolated from smallholder pig farms in Lira, Uganda. Second cycle, A2E. Uppsala: SLU, Dept. of Clinical Sciences

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Abstract

Uganda is an East African country with a fast-growing population and has one of the world’s lowest gross domestic product per capita. Most of the population live in rural areas and agriculture is the country’s most important source of income. There are about 4 million pigs in Uganda, most are kept at smallholder farms, where they are an important source of income, and are most often sold to traders when in need of money. Only 5% of the pig-keepers in Uganda hold the pigs for own consumption. The traders often sell the pigs to slaughter slabs were the hygiene is suboptimal.

Antibiotic resistance is one of the great global concerns of our time. Bacterial resistance can be both natural and acquired and can be transferred in-between bacteria. The acquired resistance is driven by natural selection and use of antibiotic drugs. Therefore, the use of antibiotics must be controlled, especially the treatment of animals. In some places the misuse of antibiotics is vast, and it is sometimes used prophylactically and as growth promotors. The use of antibiotics is uncontrolled, and drugs can be bought over the counter in many places around the world, Uganda is an example of such a place. Moreover, bacteria carrying genes for antibiotic resistance can spread from animals to humans via the food-chain. In some countries, including Sweden, there are national surveillance programs to observe the use of antibiotics and the resistance in the population. One strategy of surveillance is to use indicator-bacteria, investigating resistance in a normal intestinal bacterium such as Escherichia (E.) coli to indicate the overall resistance and selective pressure in a population.

In this study, pigs from twenty smallholder farms around Lira in northern Uganda, were sampled and investigated regarding the presence of antibiotic resistance, using E. coli as an indicator bacterium. The farmers were also interviewed on their use of antibiotic drugs. The results showed that 67% of the farms had treated their pigs with antibiotics during the last year. Out of the 53 samples, 88% were resistant to sulfamethoxazole, 54% to tetracycline and 17% to trimethoprim. Further, 19% were multidrug resistant, e.g. resistant to three or more antibiotic classes.

Main title:Resistant E. coli isolated from smallholder pig farms in Lira, Uganda
Authors:Selling, Kristin
Supervisor:Jacobson, Magdalena and Ikwap, Kokas and Hansson, Ingrid and Fernström, Lise-Lotte and Gertzell, Elin
Examiner:Wallgren, Per
Series:UNSPECIFIED
Volume/Sequential designation:UNSPECIFIED
Year of Publication:2020
Level and depth descriptor:Second cycle, A2E
Student's programme affiliation:VY002 Veterinary Medicine Programme 330 HEC
Supervising department:(VH) > Dept. of Clinical Sciences
Keywords:Escherichia coli, E. coli, antibiotic resistance, Pig, Swine, Uganda, Africa
URN:NBN:urn:nbn:se:slu:epsilon-s-16132
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-s-16132
Subjects:Animal diseases
Language:English
Deposited On:15 Oct 2020 13:26
Metadata Last Modified:16 Oct 2020 01:03

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