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Foschi, Gabriella, 2008. Nucleotide metabolism and urate excretion in the Dalmatian dog breed. SLU, Dept. of Anatomy, Physiology and Biochemistry, Uppsala. Uppsala: SLU, Dept. of Anatomy, Physiology and Biochemistry

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Abstract

The purpose of this literature study is to give an overview of nitrogen and purine metabolism in general and in particular of the molecular mechanisms for the higher uric acid excretion in Dalmatian dogs. The character portrayed by the Dalmatian breed appears to be connected whit a malfunction within purine metabolism, some studies point at a kidney disease whereas other at a liver disease. Although there is a difference in renal handling of urate between purebred Dalmatians and other breeds, the transport mechanism of urate into hepatic cells is most likely a major contributing factor to the higher excretion of uric acid. Findings of different urine composition between the sexes may in the future give rise to new treatments. The differences in purine metabolism and the typical spots of the Dalmatian dogs appears to be affected by pleiotropy and are both inherited by means of a classic Medelian autosomal pattern. All purebred dogs of this breed are affected and portray a high uric acid excretion; the possible elimination of this trait is unlikely due to pleiotropic interactions. More studies on the subject are needed and are of importance as they provide, within comparative medicine, tools for understanding liver and kidney diseases connected to stone formation.

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Denna litteratur studie har som syfte att ge en översiktlig inblick i nitrogen och purinmetabolismen samt att specifikt behandla de molekylära mekanismerna för den höga urinsyrautsöndringen hos Dalmatiner hundar. Denna egenskap verkar kopplad till en rubbning av purinmetabolismen, några studier pekar på en njursjukdom och andra på en leversjukdom. Även om man har uppvisat en skillnad i urathanteringen mellan Dalmatiner och andra hundraser verkar transportmekanismen av urat, in i lever celler, vara en viktig påverkande faktor för den höga uratutsöndringen. Skillnaderna i purinmetabolism och de rastypiska prickarna verkar kopplade genom pleiotropi och ärvs genom ett klassiskt Mendeliansk autosomalt mönster. Alla renrasiga Dalmatiner är påverkade och uppvisar den höga urinsyrautsöndringen; det verkar osannolikt att få bort denna egenskap genom avel på grund av de pleiotropiska interaktionerna. Ytterligare komparativa studier inom ämnet behövs och är av vikt eftersom de kan ge verktyg för en bättre förståelse av njur- och leversjukdomar kopplade till stenbildning.

Main title:Nucleotide metabolism and urate excretion in the Dalmatian dog breed
Authors:Foschi, Gabriella
Supervisor:Eriksson, Staffan
Examiner:UNSPECIFIED
Series:UNSPECIFIED
Volume/Sequential designation:UNSPECIFIED
Year of Publication:2008
Level and depth descriptor:Other
Student's programme affiliation:1010A Agriculture Programme (admitted before July 1, 2007) 270 HEC
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Keywords:uric acid, urolithiasis, Dalmatian, purine metabolism, allopurinol
URN:NBN:urn:nbn:se:slu:epsilon-s-8641
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-s-8641
Subjects:SLU > (VH) > Dept. of Anatomy, Physiology and Biochemistry
Animal physiology and biochemistry
Language:English
Deposited On:07 Nov 2017 09:26
Metadata Last Modified:07 Nov 2017 09:26

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