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Olofsson, Linda, 2010. Fenylbutazon - tillåta vid tävling?. First cycle, G2E. Uppsala: SLU, Dept. of Biomedical Sciences and Veterinary Public Health

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Abstract

Phenylbutazone has been discussed in the world of the equestrian sport several times and different countries have diverse opinions on its use in competitions. The progressive list that permits phenylbutazone with plasma levels up to 8 µg/ml was presented at the FEI General Assembly in November 2009. The list was voted to be accepted, but later several countries realized the consequences and after protests the list was rejected and is going to be discussed again at the FEI General Assembly 2010. In this literature study I have studied the relationship between the concentrations of phenylbutazone in plasma and the effects on lameness. The purpose was to establish whether the limit of 8 µg/ml phenylbutazone in plasma affects the equestrian sport. In addition I have also studied the adverse reactions of phenylbutazone. Phenylbutazone was introduced in veterinary medicine in the 1950s and many scientific studies have been performed.
The duration of phenylbutazone is long and may depend on the accumulation in inflamed tissue. The dose 2 mg/kg gives maximum effect and higher doses prolong the duration. Studies have proved that concentrations < 2 µg/ml will reduce mild lameness and that concentrations < 8 µg/ml will reduce severe lameness. Common adverse reactions of phenylbutazone are gastric ulcers, renal papillary necrosis and hematological disturbances. Other unwanted effects are increased heart rate and right atrial pressure and also suppression of proteoglycan synthesis in articular cartilage. Adverse reactions are most common in horses treated with phenylbutazone in doses higher than recommended and administrated for longer periods than recommended, but there is also an individually sensitivity. In addition, phenylbutazone also seems to have more adverse reactions than other NSAIDs. Permitting therapeutic concentration of phenylbutazone in competitions will damage the reliability of the sport and both horses and riders could be in risk of danger.

Main title:Fenylbutazon - tillåta vid tävling?
Authors:Olofsson, Linda
Supervisor:Tydén, Eva
Examiner:Tydén, Eva
Series:Veterinärprogrammet, examensarbete för kandidatexamen / Sveriges lantbruksuniversitet, Institutionen för biomedicin och veterinär folkhälsovetenskap (t.o.m. 2015)
Volume/Sequential designation:2010:2
Year of Publication:2010
Level and depth descriptor:First cycle, G2E
Student's programme affiliation:VY002 Veterinary Medicine Programme 330 HEC
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Keywords:fenylbutazon, ridsport, doping, hästar
URN:NBN:urn:nbn:se:slu:epsilon-6-173
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-6-173
Language:Swedish
Deposited On:22 Apr 2010 08:05
Metadata Last Modified:08 Oct 2012 12:07

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